Abstract: Angiopoietin and corresponding Tie tyrosine kinase receptors constitute the Ang-Tie signaling pathway, which plays an important role in the development of ocular and the pathological process of ischemic and neovascular diseases. During the development of the eyeball, the Ang-Tie signaling pathway is involved in the development of retinal blood vessels, the regression of primitive vitreous blood vessels, and the development of the drainage channels of aqueous humor in the corners. In mature individuals, the Ang-Tie signaling pathway plays an important role in maintaining blood vessel stability. Its imbalance can destroy the barrier function of endothelial cells, leading to pathological changes such as vascular leakage, and is widely involved in vascular diseases in the retina, choroid, and cornea. In addition, there are currently a variety of Ang-Tie pathway-related drugs for eye diseases and are under development. (Int Rev Ophthalmol, 2021, 45: 335-340)

Key words: angiopoietin, Ang-Tie signaling pathway, ocular development